Sun, D., Sang, Z., Kim, J., Xiang, Y., Cohen, T., Belford, A., Huet, A., Sun, J., Conway, J., Schneidman-Duhovny, D., Taylor, D., Zhang, C., Huang, W., & Shi, Y. (2021). Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting novel and conserved epitopes. Nat. Comm. In Revision.

Robinson, N.J., Miyagi, M., Scarborough, J.A., Scott, J.G., Taylor, D.J., & Schiemann, W.P. (2021). RAP1 SUMOylation by SLX4IP-PIAS1 Coordinates Telomere Maintenance through NF-kB and Notch Signaling. Science Signaling. In Press.

Xu, M., Axhemi, A., Malgowska, M., Chen, Y., Leonard, D., Srinivasan, S., Jankowsky, J., & Taylor, D.J. (2021). Active and passive destabilization of G-quadruplex DNA by the telomere POT1-TPP1 complex. J Mol Biol. 2021 Feb 4;433(7):166846. doi: 10.1016/j.jmb.2021.166846. PMID: 33549587. Cover: Volume 433, Issue 13. 25 June 2021.


Mangosh, T.L., Awadallah, W.N., Grabowska, M.M., & Taylor, D.J. (2020). SLX4IP-mediated telomere maintenance is essential for androgen receptor-independent castration- resistant prostate cancer. Mol Cancer Res. doi: 10.1158/1541-7786.MCR-20-0314. PMID: 33188147.

Wang, Y., Song, Q., Huang, W., Lin, Y., Wang, X., Wang, C., Willard, B., Zhao, C.& Nan, J., Holvey-Bates, E., Wang, Z., Taylor, D., Yang, J., Stark, G. R. (2020). A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses. Cell research, 1-13. PMID: 32759968

Leonard, D.*, Huang, W.*, Izadmehr, S., O’Connor, C.M., Wiredja, D., Wang, Z., Zaware, N., Chen, Y., Schlatzer, D., Kiselar, J., Vasireddi, N., Schuchner, S., Perl, A.L., Galsky, M., Xu., W., Brautigan, D., Ogris, E., Taylor, D.J., & Narla, G. (2020). Small molecule selectively enhances phosphatase function through biased heterotrimer stabilization. Cell. 181(3): 688-701.E16. PMID: 32315618.

  • Spotlight Article with Preview: Westermarck, J. & Neel, B.G. (2020) Piecing together a broken tumor suppressor phosphatase for cancer therapy. Cell. 181(3): 514-517. PMID: 32359434.
  • Research Highlight: Willson, J. (2020) Selective stabilization supports phosphatase targeting in cancer. Nature Reviews Drug Discovery. 2020 May 11. doi: 10.1038/d41573-020-00091-3. PMID: 32393817.
  • Research Watch: by Cancer Discovery editorial staff. (2020). PP2A Activators Stabilize PP2A Complexes with Differing Specificities. Jul;10(7):OF9. doi: 10.1158/2159-8290.CD-RW2020-073. Epub 2020 May 15. PMID: 32414905.
  • Research Spotlight: Shah, V.M., English, I.A., & Sears, R.C. (2020) Select stabilization of a tumor suppressive PP2A heterotrimer. Trends in Pharmacological Sciences. 2020 Jul 2;S0165-6147(20)30144-9. doi: 10.1016/ PMID: 32624198.
  • Faculty Opinions Recommended: Yu, E. (2020) Selective PP2A Enhancement through Biased Heterotrimer Stabilization. In Faculty Opinions, 11 May 2020; doi: 10.3410/f.737780632.793574081.

Robinson, N.J., Morrison-Smith, C.D., Gooding, A.J., Schiemann, B.J., Chang, J., Jackson, M.W., Taylor, D.J., & Schiemann, W.P. (2020). SLX4IP regulates telomere maintenance and Wnt signaling to control breast cancer metastasis. Life Sciences Alliance. 2020 Apr. 3(4):e201900427. doi: 10.26508/lsa201900427. PMID: 32071280.

Morgan, C., Huang, W., Rudin, S., Taylor, D., Kirby, J., Bonomo, R., and Yu, E. (2020). Cryo-EM structure of the Acinetobacter baumannii 70S ribosome and implications for new antibiotic development. mBio. 2020 Jan-Feb; 11(1): e03117-19. doi: 10.1128/mBio.03117-19. PMID: 31964740.


Su, C-C., Kambakam, S., Rajavel, M., Morgan, C.E., Scott, H., Huang, W., Emerson, C., Taylor, D.J, Stewart, P.L., Bonomo, R., & Yu, E.W. (2019). Cryo-EM structure of an Acinetobacter baumanii multidrug efflux pump. mBio. July 2;10(4). PMID: 31266873.

Xu, M., Kiselar, J., Whited, T.L., Hernandez-Sanchez, W., & Taylor, D.J. (2019). POT1-TPP1 differentially regulates telomerase via POT1 His266 and as a function of single-stranded telomere DNA length. PNAS. 116(47): 23527-23533. PMID: 31685617

Hernandez-Sanchez, W., Huang, W., Plucinsky, B., Garcia-Vazquez, N., Robinson, N.J., Schiemann, W.P., Berdis, A.J., Skordalakes, E., & Taylor, D.J. (2019) A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. PLOS Biology. Epub April 5, 2019. PMID: 30951520.

Robinson, N.R., Taylor, D.J., & Schiemann, W.S. (2019) Stem Cells, Immortality, and the Evolution of Metastatic Properties in Breast Cancer. J. Cancer Metastasis Treat. 5:39. 10.20517/2394-4722.2019.15 PMID: 31440584


Zeng, X., Hernandez-Sanchez, W., Xu, M., Whited, T.L., Baus, D., Zhang, J., Berdis, A.J., & Taylor, D.J. (2018) Induction of cancer cell death by telomerase-mediated incorporation of a nucleoside analog into telomeric DNA. Cell Reports. 23: 3031-3041. PMID: 29874588.

Basak, S., Gicheru, Y., Samanta, A., Molugu, S., Huang, W., de la Fuente, M., Hughes, T., Taylor, D.J., Nieman, M., Moiseenkova-Bell, V., & Chakrapani, S. (2018) Cryo-EM structure of the full-length 5-HT3A receptor in its resting conformation. Nat. Comm. Feb 6;9(1):514. PMID: 29410406.

Whited, T.L & Taylor, D.J. (2018) Expanding the chemotherapeutic potential of an established nucleoside analog to selective targeting of telomerase. Molecular and Cellular Oncology. 5(6):e1536844: doi: 10.1080/23723556.2018.1536844. PMID: 30525101

Scott, H., Huang, W., Bann, J.G., & Taylor, D.J. (2018) Advances in structure determination by cryo-EM to unravel membrane-spanning pore formation. Protein Science. 27(9):1544-1556. PMID: 30129169


Scott, H., Kim, J-K., Yu, C., Huang, L. Qiao, F., & Taylor, D.J. (2017) Spatial organization and molecular interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 shelterin complex. J. Mol. Biol. 429:2863-2872. PMID: 28807855.


Rajavel, M., Orban, T., Xu, M., Hernandez-Sanchez, W., de la Fuente, M., Palczewski, K., & Taylor, D.J. (2016) Dynamic peptides of human TPP1 fulfill diverse functions in telomere maintenance. Nucl. Acids Res. 44(21): 10467-10479. PMID: 27655633.

Mullins, M.R., Rajavel, M., Hernandez-Sanchez, W., de la Fuente, M., Biendarra, S., Harris, M.E., & Taylor, D.J. (2016) POT1-TPP1 binding and unfolding of telomere DNA discriminates between structural polymorphisms. J. Mol. Biol. 428(13):2695-2708.  PMID: 27173378.

Bhardwaj, A., Sankhala R.S., Olia, A.S., Brooke, D., Casjens, S.R., Taylor, D.J., Prevelige Jr., P.E., & Cingolani, G. (2016) Structural plasticity of the protein plug that traps newly packaged genomes in Podoviridae virions. J. Biol. Chem. 291:215-226.  PMID: 26574546.

Ying, W., Deng O., Feng, Z., Du, Z., Xiong, X., Lai, J., Yang, X., Wang, H., Xu, M., Taylor, D., Yan, C., Chen, C., Difeo, A., Ma, Z., Zhang, J. (2016) RNF126 promotes homologous recombination via regulation of E2F1-mediated BRCA1 expression. Oncogene.  35: 1363-1372.  PMID: 26234677.

Hernandez-Sanchez, W., Xu, M., & Taylor, D.J. (2016) Chapter 21: Telomere Maintenance and Genome Stability.  In: Kovalchuk, I & Kovalchuk, O (eds.), Genome Stability. From Virus to Human Application, pp. 353-372. Elsevier/Academic Press.


des Georges, A., Hasem, Y., Unbehaun, A., Grassucci, R. A., Taylor, D., Hellen, C. U. T., Pestova, T. V., & Frank, J. (2014) Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP. Nucl. Acids Res., 42:3409-3418. PMID: 24335085.

Rajavel, M., Mullins, M. R., & Taylor, D.J. (2014) Multiple facets of TPP1 in telomere DNA maintenance. Biochim Biophys Acta Proteins & Proteomics. 1844:1550-1559.  PMID: 24780581

Corriveau, M., Mullins, M.R., Baus, D., Harris, M.E., & Taylor, D.J. (2013) Coordinated Interactions of Multiple POT1-TPP1 Proteins with Telomere DNA. J. Biol. Chem. 288:16361-70. PMID: 23616058

Tsybovsky, Y., Orban, T., Molday, R.S., Taylor, D., & Palczewski, K. (2013) Molecular organization and ATP-induced conformational changes of ABCA4, the photoreceptor-specific ABC transporter.  Structure, 21:854-860. PMID: 23562398

Lobo, G.P., Amengual, J., Baus, D., Shivdasani, R.A., Taylor, D., & von Lintig, J. (2013) Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.  J. Biol. Chem., 288:9017-9027. PMID: 23393141

Komar, A.A., Taylor, D.J. and Merrick, W.C. (2013) Eukaryotic Protein Biosynthesis: The Elongation Cycle. In: Lennarz, W.J. and Lane, M.D. (eds.) The Encyclopedia of Biological Chemistry, Vol. 2, pp. 249-255. Waltham, MA: Academic Press.

Taylor, D., Unbehaun, A., Li, W., Das, W., Lei, S., Lao, H., Grassucci, R.A., Pestova, T.V., & Frank, J. (2012) Cryo-EM structure of the mammalian eRF1-eRF3-associated termination complex.  Proc Natl Acad Sci U S A, 109:18413-8. PMID: 23091004.  

Krokowski, D., Gaccioli, F., Majumder, M., Mullins, M.R., Yuan, C.L., Papadopoulou, B., Merrick, W.C., Komar, A.A., Taylor, D., & Hatzoglou, M. (2011) Characterization of hibernating ribosomes in mammalian cells. Cell Cycle. 10(16):1-12. PMID:21768774.

Taylor, D.J., Podell, E.R., Taatjes, D.J., & Cech, T.R. (2011) Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA.  J. Mol. Biol. 410:10-17. PMID: 21596049.

Speir, J.A., Taylor, D.J., Natarajan, P., Pringle, F.M., Ball, L.A. & Johnson J. E. (2010) Evolution in Action: N and C Termini of Related T=4 Viruses Exchange Roles as Molecular Switches. Structure. 18:700-709. PMID: 20541507.

Taylor, D. J., Devkota, B., Huang, A., Topf, M., Narayanan, E., Sali, A., Harvey, S., & Frank, J. (2009) Comprehensive Molecular Structure of the Eukaryotic Ribosome. Structure. 17:11591-1604. PMID: 20004163.

  • Spotlight Article with Preview: Dinman, J.D. & Kinzy, T.G. (2009) Expanding the Ribosomal Universe.  Structure.  17:1547-8.

Shi, Y., Di Giammartino, D.C., Taylor, D., Sarkeshik, A., Rice, W.J., Yates III, J.R., Frank, J., & Manley, J.L. (2009) Molecular Architecture of the Human pre-mRNA 3’ Processing Complex. Mol. Cell. 33:365-376. PMID: 19217410.

Grassucci, R. A., Taylor, D., and Frank, J. (2008) Visualization of Macromolecular Complexes using Cryo-Electron Microscopy with FEI Tecnai Transmission Electron Microscopes.  Nat Protoc., 3:330-339. PMID: 18274535.

Grassucci, R. A., Taylor, D. J., and Frank, J. (2007) Preparation of Macromolecular Complexes for Cryo-Electron Microscopy.  Nat Protoc., 2:3239-3246. PMID: 18079724.

Frank, J., Gao, H., Sengupta, J., Gao, N., & Taylor, D.J. (2007) The process of mRNA-tRNA Translocation.  Proc Natl Acad Sci U S A, 104:19671-8. PMID: 18003906.

Taylor, D.J., Nilsson, J., Merrill, A.R., Andersen, G.R., Nissen, P., and Frank, J. (2007) Structures of modified eEF2•80S ribosome complexes reveal the role of GTP hydrolysis in translocation.  EMBO J. 26: 2421 – 2431. PMID: 17446867.

Taylor, D.J., Frank, J., and Kinzy, T.G., (2007) Eukaryotic ribosome and elongation factors.  In Translational Control in Biology and Medicine. (ed. by Mathews, M.B., Sonenberg, N., and Hershey, J.B.) pp. 59 – 85. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York.

Taylor, D.J., Speir, J.A., Reddy, V., Cingolani, G., Pringle, F.M., Ball, L.A., and Johnson, J.E. (2006) Preliminary x-ray characterization of authentic providence virus and attempts to express its coat protein gene in recombinant baculovirus. Arch Virol, 151: 155-165. PMID: 16211330.

Taylor, D.J., and Johnson, J.E., (2005) Folding and Particle Assembly are Disrupted by Single Point Mutations near the Auto-catalytic Cleavage Site of Nudaurelia capensis  virus Capsid Protein. Protein Sci. 14: 401-408. PMID: 15659373.

Bothner, B., Taylor, D., Jun, B., Lee, K.K., Siuzdak, G., Schultz, C.P., and Johnson, J.E. (2005) Maturation of a tetravirus capsid alters the dynamic properties and creates a metastable complex. Virol, 334: 17-27. PMID: 15749119.

Lee, K.K., Tang, J., Taylor, D., Bothner, B., Johnson, J.E. (2004) Small compounds targeted to subunit interfaces arrest maturation in a nonenveloped, icosahedral animal virus. J. Virol., 13: 7208-7216. PMID: 15194797.

Taylor, D.J., Wang, Q., Bothner, B., Natarajan, P., Finn, M.G., Johnson, J.E. (2003) Correlation of chemical reactivity of Nudaurelia capensis omega virus with a pH-induced conformational change.  Chem. Comm., 22: 2770-2771. PMID: 14651097.

Taylor, D.J., Krishna, N.K., Canady, M.A., Schneemann, A., and Johnson, J.E. (2002) Large Scale, pH-Dependent, Quaternary Structure Changes in an RNA Virus Capsid are Reversible in the Absence of Subunit Autoproteolysis. J. Virol., 76: 9972-9980. PMID: 12208973.