Department of Pharmacology · Case Western Reserve University
Welcome to the Taylor Lab
From molecular structure to new therapeutics
We integrate molecular structure with functional phenotypes to understand fundamental biological processes, then use that insight to design new therapeutic strategies.
What we study
All research
01
Protein Phosphatase 2A
How biogenesis, assembly and post-translational modifications shape the substrate specificity of the PP2A family of phosphatases.
02Telomeres and Telomerase
How telomere end-binding proteins protect chromosome ends from the DNA damage response and regulate telomerase.
03Drug Design
Structure-guided design of telomerase-targeting nucleotide analogs, small molecule activators of PP2A (SMAPs) and 15-PGDH inhibitors.
